Monthly Archives: March 2012

Cell polarity proteins and cancer

A10 IDENEllenbroek, S.I.J., Iden, S., Collard, J.G., Semin Cancer Biol. 2012 Jun;22(3):208-15. doi: 10.1016/j.semcancer.2012.02.012. Epub 2012 Mar 23.

Abstract   Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity...   Read More

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ EMBO J. 2012 Mar;31(5):1293-307 PMID: 22252130...   Read More

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

A10 IDENIden, S., Misselwitz, S., Peddibhotla, S., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., Ebnet, K., J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143. Epub 2012 Feb 27

Abstract   The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions...   Read More

The p53 network: cellular and systemic DNA damage responses in aging and cancer

A7 SCHUMACHER Reinhardt HC, Schumacher B. Trends Genet. 2012 Mar;28(3):128-36.

Abstract Genome instability contributes to cancer development and accelerates age-related pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid syndromes that...   Read More

Stem cell dynamics in sebaceous gland morphogenesis in mouse skin

A3 NIEMANNFrances, D., and Niemann. C., Dev Biol. 2012 Mar 1;363(1):138-46. doi: 10.1016/j.ydbio.2011.12.028. Epub 2011 Dec 27.

Abstract The hair follicle (HF) and the sebaceous gland (SG) constitute the two integral parts of the pilosebaceous unit and significantly contribute to the...   Read More

Role of NF-κB in epithelial biology

A4 PASPARAKISPasparakis, M., Immunol Rev. 2012 Mar;246(1):346-58. doi: 10.1111/j.1600-065X.2012.01109.x.

Abstract Since its discovery, nuclear factor-κB (NF-κB) has been recognized as a critical regulator of immune responses. While early studies focused on studying the...   Read More

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