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Monthly Archives: July 2013

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

A5 BRÜNING/NIESSEN Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC, Niessen CM; Dev Cell. 2013 Jul 29;26(2):176-87. doi: 10.1016/j.devcel.2013.05.017

Abstract   The multilayered epidermis is established through a stratification program, which is accompanied by a shift from symmetric toward asymmetric divisions (ACD), a...   Read More

Indian hedgehog controls proliferation and differentiation in skin tumorigenesis and protects against malignant progression.

A3 NIEMANNKakanj P, Reuter K, Séquaris G, Wodtke C, Schettina P, Frances D, Zouboulis CC, Lanske B, Niemann C; Cell Rep. 2013 Jul 25;4(2):340-51. doi: 10.1016/j.celrep.2013.06.037. Epub 2013 Jul 18.

Abstract   Mutations in the hedgehog pathway drive the formation of tumors in many different organs, including the development of basal cell carcinoma in...   Read More

ILK: a pseudokinase with a unique function in the integrin-actin linkage

A11 WICKSTRÖM

Ghatak S, Morgner J, Wickström SA Biochem. Soc. Trans. 2013 Aug;41(4):995-1001 PMID: 23863169 Abstract ILK (integrin-linked kinase) is a central component of cell-matrix adhesions...   Read More

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

B7 EMING

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT,...   Read More

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

B3 ECKES KRIEGDeppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B; J Clin Invest. 2013 Jul 1. pii: 69210. doi: 10.1172/JCI69210. [Epub ahead of print]

Abstract Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet organelles, ?-granules, release proteins...   Read More

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