Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug

August 26, 2013B12 SENGLE Tamminen JA, Parviainen V, Rönty M, Wohl AP, Murray L, Joenväärä S, Varjosalo M, Leppäranta O, Ritvos O, Sengle G, Renkonen R, Myllärniemi M, Koli K; Oncogenesis. 2013 Aug 26;2:e66. doi: 10.1038/oncsis.2013.29.

Abstract Malignant mesothelioma is a form of cancer that is highly resistant to conventional cancer therapy for which no major therapeutic advances have been... Read More

T-cadherin is essential for adiponectin-mediated revascularization

August 26, 2013B14 DENZEL

Parker-Duffen JL, Nakamura K, Silver M, Kikuchi R, Tigges U, Yoshida S, Denzel MS, Ranscht B, Walsh K J. Biol. Chem. 2013 Aug;288(34):24886-97 PMID:... Read More

Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice (2012)

August 15, 2013publicationsMokkapati, S., Bechtel, M., Reibetanz, M., Miosge, N., and Nischt, R., J Histochem Cytochem. 2012 Apr;60(4):280-9. doi: 10.1369/0022155412436586. Epub 2012 Jan 19.

Abstract Nidogen 1 and 2 are ubiquitous basement membrane (BM) components. They show a divergent expression pattern in certain adult tissues with a prominent... Read More

Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier (2012)

August 15, 2013publicationsJohn, S., Thiebach, L., Frie, C., Mokkapati, S., Bechtel, M., Nischt, R., Rosser-Davies, S., Paulsson, M., and Smyth N., PLoS One. 2012;7(4):e34252. doi: 10.1371/journal.pone.0034252. Epub 2012 Apr 4.

Abstract Transglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization.... Read More

Expression of collagen VI α5 and α6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis

August 15, 2013B2 WAGENER/ PAULSSONSabatelli, P., Gualandi, F., Gara, S.K., Paulsson, M., Zamparelli, A., Martoni, E., Grumati, P., Pellegrini, C., Merlini, L., Ferlini, A. Maraldi, N.M., Bonaldo, P., Squarzoni, S. and Wagener, R., Matrix Biol. 2012 Apr;31(3):187-96. doi: 10.1016/j.matbio.2011.12.003. Epub 2011 Dec 30.

Abstract Collagen VI is a major extracellular matrix (ECM) protein with a critical role in maintaining skeletal muscle functional integrity. Mutations in COL6A1, COL6A2... Read More

EMILIN- 3, a peculiar member of the EMILIN/Multimerin protein family, has a distinct expression pattern, forms oligomeric assemblies and serves as a pro TGF-

August 15, 2013B2 WAGENER/ PAULSSONSchiavinato, A., Becker, A.K., Zanetti, M., Corallo, D., Milanetto, M., Bizzotto, D., Bressan, G., Guljelmovic, M., Paulsson, M., Wagener, R., Braghetta, P. and Bonaldo, P., J Biol Chem. 2012 Mar 30;287(14):11498-515. doi: 10.1074/jbc.M111.303578. Epub 2012 Feb 10.

Abstract EMILIN-3 is a glycoprotein of the extracellular matrix belonging to a family that contains a characteristic N-terminal cysteine-rich EMI domain. Currently, EMILIN-3 is... Read More

Inhibition of integrin α2β1 ameliorates glomerular injury

August 15, 2013B3 ECKES KRIEGBorza, C.M., Su, Y., Chen, X., Yu, L., Mont, S., Chetyrkin, S., Voziyan, P., Hudson, B.G., Billings, P.C., Jo, H., Bennett, J.S., DeGrado, W.F., Eckes, B., Zent, R., and Pozzi, A., J Am Soc Nephrol. 2012 Jun;23(6):1027-38. doi: 10.1681/ASN.2011040367. Epub 2012 Mar 22.

Abstract Mesangial cells and podocytes express integrins α1β1 and α2β1, which are the two major collagen receptors that regulate multiple cellular functions, including extracellular... Read More

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation (2006)

August 15, 2013publications+Stratis, A., Pasparakis, M., Rupec, R.A., Markur, D., Hartmann, K., Scharffetter-Kochanek, K., Peters, T., van Rooijen, N., Krieg, T., and Haase, I., J Clin Invest. 2006 Aug;116(8):2094-104.

Abstract Psoriasis is a common skin disease, the pathogenesis of which has not yet been resolved. In mice, epidermis-specific deletion of inhibitor of NF-kappaB... Read More

Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin (2007)

August 15, 2013publicationsRebholz, B., Haase, I., (corresponding author), Eckelt, B., Kuprash, D.V., Nedospasov, S.A., Flaig, M.J., Mailhammer, R., Weindl, G., Förster, I., Huss, R., Schmid, R.M., Pfeffer, K., and Rupec, R.A., Immunity. 2007 Aug;27(2):296-307. Epub 2007 Aug 9.

Abstract Inflammatory diseases at epithelial borders develop from aberrant interactions between resident cells of the tissue and invading immunocytes. Here, we unraveled basic functions... Read More

Resolving lesions in human cutaneous leishmaniasis predominantly harbour chemokine receptor CXCR3-positive T helper 1/T cytotoxic type 1 cells (2010)

August 15, 2013publicationsGeiger, B., Wenzel, J., Hantschke, M., Haase, I., Ständer, S., and von Stebut, E., Br J Dermatol. 2010 Apr;162(4):870-4. doi: 10.1111/j.1365-2133.2009.09573.x. Epub 2009 Nov 10.

Abstract BACKGROUND: Cutaneous leishmaniasis (CL) is an epidemic disease affecting millions of individuals worldwide. Treatment options have several side-effects and a vaccine does not... Read More

Yearly Archives: 2013