Monthly Archives: February 2014

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

publicationsDe Craene B, Denecker G, Vermassen P, Taminau J, Mauch C, Derore A, Jonkers J, Fuchs E, Berx G; Cell Death Differ. 2014 Feb;21(2):310-20. doi: 10.1038/cdd.2013.148. Epub 2013 Oct 25.

Abstract   Expression of the EMT-inducing transcription factor Snail is enhanced in different human cancers. To investigate the in vivo role of Snail during...   Read More

NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly

publicationsMetodiev MD, Spåhr H, Loguercio Polosa P, Meharg C, Becker C, Altmueller J, Habermann B, Larsson NG, Ruzzenente B; PLoS Genet. 2014 Feb 6;10(2):e1004110. doi: 10.1371/journal.pgen.1004110. eCollection 2014.

Abstract Biogenesis of mammalian mitochondrial ribosomes requires a concerted maturation of both the small (SSU) and large subunit (LSU). We demonstrate here that the...   Read More

Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons

Neuhaus JF, Baris OR, Hess S, Moser N, Schröder H, Chinta SJ, Andersen JK, Kloppenburg P, Wiesner RJ Brain 2014 Feb;137(Pt 2):354-65 PMID: 24163249...   Read More

A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein

B2 WAGENER/ PAULSSONBecker AK, Mikolajek H, Paulsson M, Wagener R, Werner JM; Structure. 2014 Feb 4;22(2):199-208. doi: 10.1016/j.str.2013.06.028. Epub 2013 Dec 12.

Abstract Von Willebrand factor A (VWA) domains are versatile protein interaction domains with N and C termini in close proximity placing spatial constraints on...   Read More

Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane…

B3 ECKES KRIEGRubel D, Frese J, Martin M, Leibnitz A, Girgert R, Miosge N, Eckes B, Müller GA, Gross O; Matrix Biol. 2014 Feb;34:13-21. doi: 10.1016/j.matbio.2014.01.006. Epub 2014 Jan 27.

Abstract Maturation of the glomerular basement membrane (GBM) is essential for maintaining the integrity of the renal filtration barrier. Impaired maturation causes proteinuria and...   Read More

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