Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

March 30, 2014A5 BRÜNING/NIESSENMauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC; Nat Immunol. 2014 May;15(5):423-30. doi: 10.1038/ni.2865. Epub 2014 Mar 30.

Abstract Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however,... Read More

Hexosamine pathway metabolites enhance protein quality control and prolong life

March 17, 2014B14 DENZEL

Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A Cell 2014 Mar;156(6):1167-78 PMID: 24630720 Abstract... Read More

Impact of genomic damage and ageing on stem cell function

March 15, 2014A7 SCHUMACHERBehrens A, van Deursen JM, Rudolph KL, Schumacher B; Nat Cell Biol. 2014 Mar;16(3):201-7. doi: 10.1038/ncb2928.

Abstract Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation... Read More

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Monthly Archives: March 2014

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Hexosamine pathway metabolites enhance protein quality control and prolong life

Impact of genomic damage and ageing on stem cell function

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