Monthly Archives: November 2014

Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation

publicationsBaggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG; Nucleic Acids Res. 2014 Dec 16;42(22):13920-38. doi: 10.1093/nar/gku1132. Epub 2014 Nov 26.

Abstract Members of the pentatricopeptide repeat domain (PPR) protein family bind RNA and are important for post-transcriptional control of organelle gene expression in unicellular...   Read More

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

A7 SCHUMACHERMueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B; Nat Cell Biol. 2014 Dec;16(12):1168-79. doi: 10.1038/ncb3071. Epub 2014 Nov 24.

Abstract Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage...   Read More

A C. elegans homolog of the Cockayne syndrome complementation group A gene

A7 SCHUMACHERBabu V, Hofmann K, Schumacher B; DNA Repair (Amst). 2014 Dec;24:57-62. doi: 10.1016/j.dnarep.2014.09.011. Epub 2014 Nov 8.

Abstract Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA...   Read More

Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions

A14 WIESNERA3 NIEMANNKloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R; J Invest Dermatol. 2015 Mar;135(3):679-89. doi: 10.1038/jid.2014.475. Epub 2014 Nov 5.

Abstract Here, we studied how epithelial energy metabolism impacts overall skin development by selectively deleting intraepithelial mtDNA in mice by ablating a key maintenance...   Read More

Genetic variation within transcriptional regulatory elements and its implications for human disease

Rada-Iglesias A Biol. Chem. 2014 Dec;395(12):1453-60 PMID: 25205712 Abstract Common human pathologies have a complicated etiology involving both genetic and environmental risk factors. Moreover,...   Read More

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