Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours

January 22, 2015A3 NIEMANNPetersson M, Reuter K, Brylka H, Kraus A, Schettina P, Niemann C; Nat Commun. 2015 Jan 22;6:5874. doi: 10.1038/ncomms6874.

Abstract Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate... Read More

Necroptosis and its role in inflammation

January 16, 2015A4 PASPARAKIS

Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis... Read More

Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8

January 15, 2015B7 EMING publicationsDing X, Lucas T, Marcuzzi GP, Pfister H, Eming SA; Cancer Res. 2015 Jan 15;75(2):330-43. doi: 10.1158/0008-5472.CAN-13-3007. Epub 2014 Nov 20.

Abstract Beta human papillomaviruses (HPV) have been suspected to be carcinogenic in nonmelanoma skin cancers (NMSC), but the basis for potential viral contributions to... Read More

Quality control mechanisms in cellular and systemic DNA damage responses

January 3, 2015A7 SCHUMACHER Ermolaeva MA, Dakhovnik A, Schumacher B; Ageing Res Rev. 2015 Sep;23(Pt A):3-11. doi: 10.1016/j.arr.2014.12.009. Epub 2015 Jan 3.

Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage... Read More

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Monthly Archives: January 2015