Monthly Archives: February 2015

Pathological implications of cadherin zonation in mouse liver

A1 NIESSENHempel M, Schmitz A, Winkler S, Kucukoglu O, Brückner S, Niessen C, Christ B; Cell Mol Life Sci. 2015 Jul;72(13):2599-612. doi: 10.1007/s00018-015-1861-y. Epub 2015 Feb 17.

Abstract Both acute and chronic liver diseases are associated with ample re-modeling of the liver parenchyma leading to functional impairment, which is thus obviously...   Read More

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels

publications Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG; J Cell Biol. 2015 Feb 16;208(4):429-42. doi: 10.1083/jcb.201411100.

Abstract Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission. Despite the established role of mitofusins (MFN1...   Read More

A role for Rac1 activity in malignant progression of sebaceous skin tumours

A3 NIEMANNFrances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C; Oncogene. 2015 Oct;34(43):5505-12. doi: 10.1038/onc.2014.471. Epub 2015 Feb 9.

Abstract The small GTPase Rac1 is crucial for maintaining stem cells (SCs) in mammalian epidermis, and Rac1 activation leads to SC expansion. Loss or...   Read More

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure

publications Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT; EMBO Mol Med. 2015 Feb 2;7(3):275-87. doi: 10.15252/emmm.201404916.

Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of...   Read More

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