Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

August 27, 2015publicationsKukat C, Davies KM, Wurm CA, Spåhr H, Bonekamp NA, Kühl I, Joos F, Polosa PL, Park CB, Posse V, Falkenberg M, Jakobs S, Kühlbrandt W, Larsson NG; Proc Natl Acad Sci U S A. 2015 Aug 24. pii: 201512131. [Epub ahead of print]

Abstract Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the... Read More

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

August 26, 2015A10 IDENTuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K; Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.

Abstract Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The... Read More

SFB 829 Guest Scientist Prof. Dr. Kathleen Green from the Northwestern University Chicago

August 20, 2015Good To Know

Epithelial Cell Death and Inflammation in Skin

August 15, 2015A4 PASPARAKIS

Kumari S, Pasparakis M Curr. Top. Microbiol. Immunol. 2015 Aug; PMID: 26275873 Abstract The presence of dying cells in inflamed tissues has been recognized... Read More

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

August 13, 2015A7 SCHUMACHEREdifizi D, Schumacher B; Biomolecules. 2015 Aug 13;5(3):1855-69. doi: 10.3390/biom5031855.

Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes.... Read More

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines

August 11, 2015A10 IDENRefaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5691-7. doi: 10.1167/iovs.15-16829.

Abstract PURPOSE: Malignant melanomas of the ocular surface (conjunctival melanoma [CM]) and within the eye (uveal melanoma [UM]) show different types of metastatic behavior.... Read More

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

August 6, 2015publicationsLagouge M, Mourier A, Lee HJ, Spåhr H, Wai T, Kukat C, Silva Ramos E, Motori E, Busch JD, Siira S; German Mouse Clinic Consortium, Kremmer E, Filipovska A, Larsson NG; PLoS Genet. 2015 Aug 6;11(8):e1005423. doi: 10.1371/journal.pgen.1005423. eCollection 2015.

Abstract We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes... Read More

Monthly Archives: August 2015