Yearly Archives: 2015

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

B2 WAGENER/ PAULSSONB3 ECKES KRIEGB7 EMINGKnipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA; Immunity. 2015 Oct 20;43(4):803-16. doi: 10.1016/j.immuni.2015.09.005.

Abstract Activation of the immune response during injury is a critical early event that determines whether the outcome of tissue restoration is regeneration or...   Read More

The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?

Sengle G, Sakai LY Matrix Biol. 2015 Sep;47:3-12 PMID: 25957947 Abstract The fibrillins, large extracellular matrix molecules, are polymerized to form “microfibrils.” The fibrillin...   Read More

Matrix metalloproteinase 14 is required for fibrous tissue expansion

B4 ZIGRINO MAUCHTaylor SH, Yeung CY, Kalson NS, Lu Y, Zigrino P, Starborg T, Warwood S, Holmes DF, Canty-Laird EG, Mauch C, Kadler KE; Elife. 2015 Sep 21;4. pii: e09345. doi: 10.7554/eLife.09345.

Abstract Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are formed is...   Read More

SFB 829 scientists were awarded with ESDR poster prizes

On the Annual ESDR Meeting 2015 in Rotterdam, three SFB829 scientists were awarded an ESDR poster prize: Katrin Schönborn, Eckes/Krieg lab, for her and...   Read More

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

A10 IDENSchlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5965-73. doi: 10.1167/iovs.15-17290.

Abstract PURPOSE: Conjunctival melanoma (CM) is an ocular surface tumor that can lead to fatal metastases. Patients developing, tumor-associated lymphangiogenesis have a significantly increased...   Read More

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells

A11 WICKSTRÖMMorgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA; Nat Commun. 2015 Sep 8;6:8198. doi: 10.1038/ncomms9198.

Abstract Stem cells reside in specialized niches that are critical for their function. Quiescent hair follicle stem cells (HFSCs) are confined within the bulge...   Read More

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

publicationsKukat C, Davies KM, Wurm CA, Spåhr H, Bonekamp NA, Kühl I, Joos F, Polosa PL, Park CB, Posse V, Falkenberg M, Jakobs S, Kühlbrandt W, Larsson NG; Proc Natl Acad Sci U S A. 2015 Aug 24. pii: 201512131. [Epub ahead of print]

Abstract Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the...   Read More

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

A10 IDENTuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K; Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.

Abstract Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The...   Read More

SFB 829 Guest Scientist Prof. Dr. Kathleen Green from the Northwestern University Chicago

Epithelial Cell Death and Inflammation in Skin

Kumari S, Pasparakis M Curr. Top. Microbiol. Immunol. 2015 Aug; PMID: 26275873 Abstract The presence of dying cells in inflamed tissues has been recognized...   Read More

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