Yearly Archives: 2015

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

A7 SCHUMACHEREdifizi D, Schumacher B; Biomolecules. 2015 Aug 13;5(3):1855-69. doi: 10.3390/biom5031855.

Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes....   Read More

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines

A10 IDENRefaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5691-7. doi: 10.1167/iovs.15-16829.

Abstract PURPOSE: Malignant melanomas of the ocular surface (conjunctival melanoma [CM]) and within the eye (uveal melanoma [UM]) show different types of metastatic behavior....   Read More

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation

publicationsLagouge M, Mourier A, Lee HJ, Spåhr H, Wai T, Kukat C, Silva Ramos E, Motori E, Busch JD, Siira S; German Mouse Clinic Consortium, Kremmer E, Filipovska A, Larsson NG; PLoS Genet. 2015 Aug 6;11(8):e1005423. doi: 10.1371/journal.pgen.1005423. eCollection 2015.

Abstract We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes...   Read More

Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish

B2 WAGENER/ PAULSSONGebauer JM, Kobbe B, Paulsson M, Wagener R; Matrix Biol. 2015 Jul 31. pii: S0945-053X(15)00124-9. doi: 10.1016/j.matbio.2015.07.001. [Epub ahead of print]

Abstract Collagen XXVIII is the last discovered member of the collagen superfamily and thus has been only sparsely investigated. We studied collagen XXVIII in...   Read More

Force generation and transmission in keloid fibroblasts: dissecting the role of mechanosensitive molecules in cell function

Schneider D, Wickström SA Exp. Dermatol. 2015 Aug;24(8):574-5 PMID: 25959359 Abstract

Correlation of Merkel cell polyomavirus positivity with PDGFR? mutations and survivin expression in Merkel cell carcinoma

B4 ZIGRINO MAUCHBatinica M, Akgül B, Silling S, Mauch C, Zigrino P; J Dermatol Sci. 2015 Jul;79(1):43-9. doi: 10.1016/j.jdermsci.2015.04.002. Epub 2015 Apr 14.

Abstract BACKGROUND: Merkel cell carcinoma (MCC) is a neuroendocrine cancer of the skin postulated to originate through Merkel cell polyomavirus (MCPyV) oncogenesis and/or by...   Read More

Par Proteins in Tumor Formation and Progression

Mescher, M., and Iden, S. (2015). Cell Polarity 2. Role in Dev. and Dis. Springer 2, 344. Book chapter.

Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice

Sengle G, Carlberg V, Tufa SF, Charbonneau NL, Smaldone S, Carlson EJ, Ramirez F, Keene DR, Sakai LY PLoS Genet. 2015 Jun;11(6):e1005340 PMID: 26114882...   Read More

Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis

A9 HAMMERSCHMIDTWestcot SE, Hatzold J, Urban MD, Richetti SK, Skuster KJ, Harm RM, Lopez Cervera R, Umemoto N, McNulty MS, Clark KJ, Hammerschmidt M, Ekker SC; PLoS One. 2015 Jun 25;10(6):e0130688. doi: 10.1371/journal.pone.0130688. eCollection 2015.

Abstract Skin disorders are widespread, but available treatments are limited. A more comprehensive understanding of skin development mechanisms will drive identification of new treatment...   Read More

Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells

B13 FABRISommer A, Fabri M; PLoS One. 2015 Jun 24;10(6):e0130395. doi: 10.1371/journal.pone.0130395. eCollection 2015.

Abstract One central mechanism, by which vitamin D regulates human immune responses, is the direct modulation of dendritic cells (DCs). However, the effect of...   Read More

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