DNA repair mechanisms in cancer development and therapy

April 23, 2015A7 SCHUMACHERTorgovnick A, Schumacher B; Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157. eCollection 2015.

Abstract: DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting... Read More

Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma

April 8, 2015B13 FABRIBruns H, Büttner M, Fabri M, Mougiakakos D, Bittenbring JT, Hoffmann MH, Beier F, Pasemann S, Jitschin R, Hofmann AD, Neumann F, Daniel C, Maurberger A, Kempkes B, Amann K, Mackensen A, Gerbitz A; Sci Transl Med. 2015 Apr 8;7(282):282ra47. doi: 10.1126/scitranslmed.aaa3230.

Abstract Infiltration by macrophages represents a characteristic morphological hallmark in high-grade lymphatic malignancies such as Burkitt’s lymphoma (BL). Although macrophages can, in principle, target... Read More

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans

April 2, 2015A7 SCHUMACHERFrommolt P, Schumacher B; Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015.

Abstract Background: High-throughput transcriptional profiling using Next-Generation Sequencing (RNA-Seq) or microarray technology have become standard tools in molecular biology. Successful investigations of gene regulatory... Read More

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

April 1, 2015A5 BRÜNING/NIESSENWensveen FM, Jelen?i? V, Valenti? S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Poli? B; Nat Immunol. 2015 Apr;16(4):376-85. doi: 10.1038/ni.3120. Epub 2015 Mar 2.

Abstract An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is associated with the... Read More

Hexosamine pathway and (ER) protein quality control

March 30, 2015B14 DENZEL

Denzel MS, Antebi A Curr. Opin. Cell Biol. 2015 Apr;33:14-8 PMID: 25463841 Abstract Aminosugars produced in the hexosamine pathway (HP) are utilized in protein... Read More

The SFB 829 Starting Grant for Female Postdoc was awarded to Dr. Snehlata Kumari

March 20, 2015Good To Know

The SFB 829 will fund Dr. Snehlata Kumari’s research for the next two years to promote her scientific independence. Dr. Kumari is interested in... Read More

Cyclic mechanical strain induces TGFβ1-signalling in dermal fibroblasts embedded in a 3D collagen lattice

March 11, 2015B3 ECKES KRIEGPeters AS, Brunner G, Krieg T, Eckes B; Arch Dermatol Res. 2015 Mar;307(2):191-7. doi: 10.1007/s00403-014-1514-2. Epub 2014 Oct 28.

Abstract Many tissues are constantly exposed to mechanical stress, e.g. shear stress in vascular endothelium, compression forces in cartilage or tensile strain in the... Read More

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

March 2, 2015B13 FABRI

Stephan A, Fabri M Exp. Dermatol. 2015 Mar;24(3):161-6 PMID: 25421224 Abstract Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized... Read More

Pathological implications of cadherin zonation in mouse liver

February 17, 2015A1 NIESSENHempel M, Schmitz A, Winkler S, Kucukoglu O, Brückner S, Niessen C, Christ B; Cell Mol Life Sci. 2015 Jul;72(13):2599-612. doi: 10.1007/s00018-015-1861-y. Epub 2015 Feb 17.

Abstract Both acute and chronic liver diseases are associated with ample re-modeling of the liver parenchyma leading to functional impairment, which is thus obviously... Read More

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels

February 16, 2015publications Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG; J Cell Biol. 2015 Feb 16;208(4):429-42. doi: 10.1083/jcb.201411100.

Abstract Mitochondria form a dynamic network within the cell as a result of balanced fusion and fission. Despite the established role of mitofusins (MFN1... Read More

Yearly Archives: 2015