A3 NIEMANN

A function for Rac1 in the terminal differentiation and pigmentation of hair

A3 NIEMANNA5 BRÜNING/NIESSEN Behrendt K, Klatte J, Pofahl R, Bloch W, Smyth N, Tscharntke M, Krieg T, Paus R, Niessen CM, Niemann C, Brakebusch C, Haase I; J Cell Sci. 2012 Feb 15;125(Pt 4):896-905. doi: 10.1242/jcs.091868. Epub 2012 Jan 24.

Abstract The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to...   Read More

TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

A3 NIEMANN Petersson M, Brylka H, Kraus A, John S, Rappl G, Schettina P, and Niemann C. (2011) EMBO J. 30: 3004-3018.

Abstract Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs). It is constantly renewed by stem and progenitor...   Read More

CF/Lef1 mediated control of lipid metabolism regulates skin barrier function

A3 NIEMANN Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser, S, Michels C, Günschmann, C, Sandhoff K, Niessen C, and Niemann C. J Invest Dermatol. Sept 2011.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well...   Read More

Alternative proteolytic processing of hepatocyte growth factor during wound repair

A3 NIEMANNB7 EMING Buchstein N, Hoffmann N, Smola H, Lang S, Paulsson M, Niemann C, Krieg T, Eming SA. Am J Pathol 174(6):2116-28.

Abstract Wound healing is a crucial regenerative process in all organisms. We examined expression, integrity, and function of the proteins in the hepatocyte growth...   Read More

Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type

Niemann C, Owens DM, Schettina P, Watt FM Cancer Res. 2007 Apr;67(7):2916-21 PMID: 17409394 Abstract The NH(2) terminus of LEF1 is frequently mutated in...   Read More

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis

Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgård R, Watt FM Proc. Natl. Acad. Sci. U.S.A. 2003 Sep;100 Suppl 1:11873-80 PMID: 12917489 Abstract...   Read More

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