A4 PASPARAKIS

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

Van TM, Polykratis A, Straub BK, Kondylis V, Papadopoulou N, Pasparakis M J. Clin. Invest. 2017 Jun;127(7):2662-2677 PMID: 28628031 Abstract The mechanisms that regulate...   Read More

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

Kondylis V, Kumari S, Vlantis K, Pasparakis M Immunol. Rev. 2017 05;277(1):113-127 PMID: 28462531 Abstract Regulated cell death pathways have important functions in host...   Read More

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M Nature 2016 Dec;540(7631):124-128 PMID: 27819681 Abstract Receptor-interacting protein kinase 1...   Read More

The tumour suppressor CYLD regulates the p53 DNA damage response

Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M Nat Commun...   Read More

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S Nature 2016 08;536(7615):215-8 PMID: 27487218 Abstract Metastasis is...   Read More

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M,...   Read More

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P,...   Read More

Epithelial Cell Death and Inflammation in Skin

Kumari S, Pasparakis M Curr. Top. Microbiol. Immunol. 2015 Aug; PMID: 26275873 Abstract The presence of dying cells in inflamed tissues has been recognized...   Read More

Necroptosis and its role in inflammation

Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis...   Read More

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

A4 PASPARAKISKumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F; Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03422.

Abstract Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor...   Read More

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