A4 PASPARAKIS

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P,...   Read More

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis

Kim C, Pasparakis M EMBO Mol Med 2014 Jul;6(7):970-83 PMID: 24952939 Abstract The nuclear factor kappa B (NF-κB) signalling pathway exhibits both tumour-promoting and...   Read More

Mechanisms regulating skin immunity and inflammation

Pasparakis M, Haase I, Nestle FO Nat. Rev. Immunol. 2014 May;14(5):289-301 PMID: 24722477 Abstract Immune responses in the skin are important for host defence...   Read More

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

A4 PASPARAKIS Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I; Immunity. 2013 Nov 14;39(5):899-911. doi: 10.1016/j.immuni.2013.10.009. Epub 2013 Nov 7.

Abstract Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays...   Read More

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

A4 PASPARAKISA7 SCHUMACHERLucas, T., Willenborg, S., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Nagy, A., Ferrara, N., Pasparakis, M., and Eming, S., Blood. 2012 Jul 19;120(3):613-25. doi: 10.1182/blood-2012-01-403386. Epub 2012 May 10.

Abstract Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are...   Read More

Role of NF-κB in epithelial biology

A4 PASPARAKISPasparakis, M., Immunol Rev. 2012 Mar;246(1):346-58. doi: 10.1111/j.1600-065X.2012.01109.x.

Abstract Since its discovery, nuclear factor-κB (NF-κB) has been recognized as a critical regulator of immune responses. While early studies focused on studying the...   Read More

The adapter protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation

A4 PASPARAKISBonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva M, Bloch W, Haase I, Pasparakis M (2011) Immunity ,2011 Oct 28;35(4):572-82. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity...   Read More

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

A4 PASPARAKIS Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M., J Clin Invest. 2011, 121(7):2781-93

Abstract Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role...   Read More

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

A4 PASPARAKIS Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M., Nature. 2011 Jul 31. doi: 10.1038/nature10273

Abstract Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). Epithelial barrier...   Read More

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