In the first two funding periods, the CRC has focused on the identification of key mechanisms controlling skin homeostasis, regeneration and skin pathology. Key... Read More
Protein quality control and ECM composition: Role of the hexosamine pathway in skin homeostasis In this project we will find out if modulation of... Read More
The Role of DNA damage and Repair in Skin Aging We will characterize the role of DNA damage in skin aging, using unique mouse... Read More
Maintenance of mitochondrial integrity in epidermal stem cells Progressive impairment of regeneration with age is partly due to a decline in tissue stem cell... Read More
Identification and characterization of major stem cell identity regulators within the epidermis The epidermis contains a great variety of functionally and spatially distinct stem... Read More
Centrosomes in mammalian skin epithelial cell fate decisions How cell fate decisions are acquired in the skin epithelium, how they change during aging and... Read More
Role of MMP-14 in connective tissue homeostasis and tumour invasion Based on the results of the previous funding period we now want to understand... Read More
Role of collagen-binding integrin receptors for cellular communication and homeostasis in the skin This project aims at establishing whether and by which mechanisms integrin-mediated... Read More
Regulation of epidermal stratification and homeostasis through contractility and density sensing How the complex but stereotyped tissue structure of the mammalian epidermis is formed,... Read More
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