Insights from the worm: the C. elegans model for innate immunity

A7 SCHUMACHERErmolaeva MA, Schumacher B; Semin Immunol. 2014 Aug;26(4):303-9. doi: 10.1016/j.smim.2014.04.005. Epub 2014 May 21.

Abstract

The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C. elegans recognizes and responds to viral, bacterial, and fungal infections. Components of the RNA interference machinery respond to viral infection, while highly conserved MAPK signaling pathways activate the innate immune response to bacterial infection. C. elegans has been particularly important for exploring the role of innate immunity in organismal stress resistance and the regulation of longevity. Also functions of neuronal sensing of infectious bacteria have recently been uncovered. Studies on nematode immunity can be instructive in exploring innate immune signaling in the absence of specialized immune cells and adaptive immunity.

 

Pubmed

  • News

  • Upcoming Events

    There are no upcoming events at this time.

  • September 2022
    M T W T F S S
     1234
    567891011
    12131415161718
    19202122232425
    2627282930  

© 2017 SFB 829

Durch die weitere Nutzung der Seite stimmst du der Verwendung von Cookies zu. Weitere Informationen

Die Cookie-Einstellungen auf dieser Website sind auf "Cookies zulassen" eingestellt, um das beste Surferlebnis zu ermöglichen. Wenn du diese Website ohne Änderung der Cookie-Einstellungen verwendest oder auf "Akzeptieren" klickst, erklärst du sich damit einverstanden.

Schließen