Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging

Neuhaus JF, Baris OR, Kittelmann A, Becker K, Rothschild MA, Wiesner RJ Neuroendocrinology 2017;104(1):72-84 PMID: 26895241 Abstract BACKGROUND: Aging is a multifactorial process characterized...   Read More

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

Troilo H, Barrett AL, Zuk AV, Lockhart-Cairns MP, Wohl AP, Bayley CP, Dajani R, Tunnicliffe RB, Green L, Jowitt TA, Sengle G, Baldock C...   Read More

The fibronectin/α3β1 integrin axis serves as molecular basis for keratinocyte invasion induced by βHPV

Heuser S, Hufbauer M, Steiger J, Marshall J, Sterner-Kock A, Mauch C, Zigrino P, Akgül B Oncogene 2016 Jan; PMID: 26804167 Abstract Organ-transplant-recipients exhibit...   Read More

Systemic DNA damage responses in aging and diseases

Ribezzo F, Shiloh Y, Schumacher B Semin. Cancer Biol. 2016 Jan; PMID: 26773346 Abstract The genome is constantly attacked by a variety of genotoxic...   Read More

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation

Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL...   Read More

Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification

Respuela P, Nikolić M, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A Cell Stem Cell 2016 Jan;18(1):118-33 PMID: 26748758 Abstract Following implantation,...   Read More

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling

Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G,...   Read More

PhD/Postdoc-Retreat 2015 at Kürten with Prof. Gian-Paolo Dotto

The 7th Graduate Retreat of the SFB 829 „Molecular Mechanisms Regulating Skin Homeostasis“ took place in December 2015 in Kürten-Hungenbach. We are very pleased that...   Read More

Longevity through DNA damage tolerance

A7 SCHUMACHERCastells-Roca L, Mueller MM, Schumacher B; Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543.

Pubmed

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

A5 BRÜNING/NIESSENB7 EMINGKnuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA; J Immunol. 2015 Dec 1;195(11):5296-308. doi: 10.4049/jimmunol.1501237. Epub 2015 Oct 30.

Abstract Myeloid cells are key regulators of tissue homeostasis and disease. Alterations in cell-autonomous insulin/IGF-1 signaling in myeloid cells have recently been implicated in...   Read More

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