Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

A1 NIESSENMertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V; Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):842-7. doi: 10.1073/pnas.1217279110. Epub 2012 Dec 31.

Abstract Cell-cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between...   Read More

PECAM1(+)/Sca1(+)/CD38(+) vascular cells transform into myofibroblast-like cells in skin wound repair

B2 WAGENER/ PAULSSONB4 ZIGRINO MAUCH Etich J, Bergmeier V, Frie C, Kreft S, Bengestrate L, Eming S, Mauch C, Eckes B, Ulus H, Lund FE, Rappl G, Abken H, Paulsson M, Brachvogel B; PLoS One. 2013;8(1):e53262. doi: 10.1371/journal.pone.0053262. Epub 2013 Jan 4.

Abstract   Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may...   Read More

Z3 Bazzi & Krieg

This project has been implemented as an Integrated Research Training Group in order to serve as a structural platform for medical students, PhD students,...   Read More

B13 Fabri

Vitamin D regulation of the skin innate immune response The extra-renal vitamin D metabolism in human immune cells is central to the outcome of...   Read More

B12 Sengle

Extracellular fibrillin microfibrils as multifunctional scaffolds integrating growth factor signalling in the skin Mutations in the fibrillin genes lead to congenital multisystem disorders with...   Read More

B11 Baumann Sengle

Structure-Function Relationships of Hsp47/SerpinH1 and its Role in Skin Fibrosis Heat shock protein Hsp47 is essential for collagen biosynthesis. Elevated HS47 levels have been...   Read More

Development and homeostasis of the sebaceous gland

Niemann C, Horsley V Semin. Cell Dev. Biol. 2012 Oct;23(8):928-36 PMID: 22960253 Abstract The important role of epidermal appendages especially the sebaceous gland has...   Read More

Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest

Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J Cell Stem Cell 2012 Nov;11(5):633-48 PMID: 22981823 Abstract Neural crest cells (NCC)...   Read More

SFB 829 PhD student & Postdoc Retreat 2012 with Arnoud Sonnenberg (Netherlands Cancer Institute) and Beate Eckes (SFB 829 PI)

Loss of epidermal MMP-14 expression interferes with angiogenesis but not with re-epithelialization

B4 ZIGRINO MAUCHZigrino, P., Ayachi, O., Schild, A., Zamek, J., Kaltenberg, J., Nischt, R., Koch, M., and Mauch, C., Eur J Cell Biol. 2012 Oct;91(10):748-56. doi: 10.1016/j.ejcb.2012.05.003. Epub 2012 Jun 18.

Abstract Synthesis and activation of matrix metalloproteinases during wound healing are important for remodeling the extracellular matrix and modulating various cellular functions. The membrane-type...   Read More

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