Microenvironmental regulation by fibrillin-1

B12 SENGLESengle, G., Tsutsui, K., Keene, D.R., Tufa, S.F., Carlson, E.J., Charbonneau, N.L., Ono, R.N., Sasaki, T., Wirtz, M.K., Samples, J.R., Fessler, L.I., Fessler, J.H., Sekiguchi, K.,Hayflick, S.J., and Sakai, L.Y., PLoS Genet. 2012 Jan;8(1):e1002425. doi: 10.1371/journal.pgen.1002425. Epub 2012 Jan 5.

Abstract   Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has...   Read More

Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation

Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS...   Read More

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

A10 IDENEllenbroek, S.I.J., Iden, S., Collard, J.G., Small GTPases. 2012 Jan-Mar;3(1):4-14. doi: 10.4161/sgtp.19379. Epub 2012 Jan 1

Abstract   Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer....   Read More

A7 Schumacher

UV-induced DNA damage in photoaging and skin homeostasis UV-induced DNA lesions promote photoaging and cause skin cancer development. We have established that UV-induced lesions...   Read More

A5 Brüning/Niessen

Metabolic control of skin morphogenesis, barrier function and development of diabetes associated skin complications            In the last funding periods we identified novel functions for...   Read More

SFB 829 PhD student & Postdoc Retreat 2011 with Karin Scharffetter-Kochanek (University of Ulm) and Bent Brachvogel (associated SFB 829 PI)

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

Rada-Iglesias A, Wysocka J Genome Med 2011 Jun;3(6):36 PMID: 21658297 Abstract Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent...   Read More

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

publications Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG. EMBO J. 2011 Nov 1.

Abstract Regulation of mtDNA expression is critical for maintaining cellular energy homeostasis and may, in principle, occur at many different levels. The leucine-rich pentatricopeptide...   Read More

Ciliopathies

publications Benzing T, Hildebrandt F, Katsanis N. (2011) New Engl J Med. 364 (16) :1533-43.

PubMed

Transition zone proteins and cilia dynamics

publications Benzing T, Schermer B. (2011) Nat Genetics, 43 (8) :723-4.

PubMed

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